We have 4 children who currently range in age from 26 to 22. Leaving them for extended periods is one of the negative sides to fulfilling our dream but we hope they and any future grandchildren will visit often and benefit from lovely holidays in beautiful parts of the world.
Also leaving my parents is a difficult choice as we don’t want our new life to impact theirs.
Don’t worry too much about either the kids or the parents. Go and do what your dream tells you while you can. I know I would not stop my kids fulfilling their dream and I well remember being very proud of my Dad when he decided to go and work in Saudi Arabia; not quite the same but !